P5-associated contaminants in AAV preparations

NIAID Data Ecosystem2026-03-13 收录

基因治疗载体质量控制

病毒载体污染物检测

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https://www.ncbi.nlm.nih.gov/sra/SRP326283 数据链接链接失效反馈

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资源简介：

Assesment of the DNA sequence contamination within rAAV preparations with a focus on those associated with the AAV P5 promoter.

创建时间：

2022-03-10

Advanced characterization of DNA molecules in rAAV vector preparations by single-stranded virus next-generation sequencing

基因治疗载体

病毒载体污染物检测

Recent successful clinical trials with recombinant adeno-associated viral vectors (rAAVs) have led to a renewed interest in gene therapy. However, despite extensive developments to improve vector-manu

DataONE2019-06-30 更新200

The SSV-Seq 2.0 PCR-free method improves the sequencing of adeno-associated viral vector genomes containing GC-rich regions and homopolymers

基因治疗载体质量控制

测序技术优化

Adeno-associated viral vectors (AAV) are efficient engineered tools for delivering genetic material into host cells. The commercialization of AAV-based drugs must be accompanied by the development of

NIAID Data Ecosystem40

Profiling vector preparations by Adeno-Associated Virus Genome Population Sequencing achieves full-genome resolution and reveals heterogenic human-vector chimeras

基因治疗载体质量控制

AAV基因组完整性分析

Recombinant adeno-associated virus (rAAV)-based gene therapy has entered a phase of clinical translation and commercialization for multiple therapeutic applications. Despite this new era for gene ther

NIAID Data Ecosystem10

Residual DNA in AAV9 sample

基因治疗载体质量控制

病毒包装机制

This study investigates the presence of residual plasmid DNA and host-cell derived nucleic acids in recombinant AAV9 vector preparations obtained from CsCl ultracentrifugation gradients. Capsid fracti

NIAID Data Ecosystem40

AAV Nanopore Seq

基因治疗载体质量控制

Nanopore测序

Monitoring of DNA contaminants in Adeno-associated virus (AAV) gene therapy vectors is of major interest, due to its clinical application with increasing therapeutic doses. We report here direct, ampl

NIAID Data Ecosystem20

P5-associated contaminants in AAV preparations

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