TOP2A

ENCODES a protein that exhibits ATP binding (ortholog); chromatin binding (ortholog); DNA binding (ortholog); INVOLVED IN cerebellar granule cell differentiation (ortholog); cerebellar Purkinje cell differentiation (ortholog); chromosome condensation (ortholog); PARTICIPATES IN doxorubicin pharmacodynamics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); adenoid cystic carcinoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN cytoplasm (ortholog); DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex (ortholog); nucleolus (ortholog); INTERACTS WITH deoxynivalenol; resveratrol

编码一种表现出ATP结合（同源物）、染色质结合（同源物）、DNA结合（同源物）特性的蛋白质；参与小脑颗粒细胞分化（同源物）、小脑浦肯野细胞分化（同源物）、染色体浓缩（同源物）过程；参与阿霉素药代动力学途径、依托泊苷药代动力学途径；与急性早幼粒细胞白血病（同源物）、腺样囊性癌（同源物）、肾上腺皮质癌（同源物）相关；存在于细胞质中（同源物）；DNA拓扑异构酶II型（双链切割、ATP水解）复合物（同源物）、核仁（同源物）；与脱氧雪腐镰刀菌烯醇、白藜芦醇相互作用。