TPH1 gene expression

TPH1 (Tryptophan hydroxylase 1) is one of two tryptophan hydroxlyase enzymes that catalyze the rate-limiting step in the synthesis of 5-HT (5-hydroxytryptamine or serotonin). TPH1 is expressed in the gut, the periphery and in the pineal gland and additionally has roles during neuronal development. In contrast, TPH2 is expressed at high levels in the brain and the gut (Walther et al, 2003; Côté et al, 2003; Nakamura et al, 2006).
TPH1 has been shown to be a transcriptional target of EGR1 and is transcriptionally activated downstream of sustained NGF signaling (Grasberer et al, 2013; Mullenbrock et al, 2011; Adams et al, 2017).

TPH1（色氨酸羟化酶1）是催化5-HT（5-羟色胺或血清素）合成限速步骤的两个色氨酸羟化酶酶之一。TPH1在肠道、周围组织和松果体中表达，并在神经元发育过程中发挥重要作用。相反，TPH2在脑部和肠道中高水平表达（参见Walther等，2003年；Côté等，2003年；Nakamura等，2006年）。研究表明，TPH1是EGR1的转录靶点，并且在持续的NGF信号传导下游被转录激活（参见Grasberer等，2013年；Mullenbrock等，2011年；Adams等，2017年）。