Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation. Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation

The LX2 cells were subjected to TGFβ (5ng/ml) stimulus with or without STING inhibitor IFM-004490-7 10μM (STINGX) pretreatment. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different groups (Control, TGFβ, STINGX+TGFβ) Overall design: Comparative gene expression profiling analysis of RNA-seq data for LX2 cells untreated or subjected to TGFβ with or without STINGX pretreatment.