OAS-mediated antiviral response
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Figure 1 The OAS family in antiviral pathways. Following virus infection of a host cell, viral dsRNA stimulates OAS1, OAS2 and OAS3 and leads to the synthesis of 2′-5′ oligoA and RNase L activation. Activated RNase L cleaves viral and cellular RNA. MDA5 and RIG-I detect cleaved viral RNA, thereby promoting the activation of IRF3 and IRF7. The hOASL binds to RIG-I and enhances the sensitivity of RIG-I signaling through the UBL domain, whereas the mOASL1 binds to IRF7 mRNA and inhibits the translation of IRF7.
创建时间：
2020-07-09
