The loss of Nudt15 thiopurine detoxification enhances direct DNA damage in hematopoietic stem cells (HSCs)
收藏NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP400567
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The kinetics of HSCs after 6-MP administration were examined by flow cytometry analysis, and genes differentially expressed between HSCs from Nudt15+/+ mice and HSCs from Nudt15R138C/R138C mice were identified by RNA-sequencing before the appearance of 6-MP-induced HSC damage. Overall design: HSCs extracted from Nudt15+/+ and Nudt15R138C/R138C mice treated with 6-MP were analyzed by comparative gene expression profiling using RNA-seq.
创建时间：
2023-09-09
