Ichthyosis molecular fingerprinting shows profound Th17-skewing and a unique barrier genomic signature

The purpose of this study was to analyze the genomic signatures and profiles of skin from ichthyosis (various subtypes) vs. healthy patients. The analysis strategy was to study differentially expressed genes common to the ichthyosis shared phenotype, as well as individual ichthyosis subtypes, and compare and contrast to the genomic profiles of atopic dermatitis and psoriasis. Skin biopsy samples from 21 patients with ichthyosis (3 Netherton, 7 lamellar ichthyosis/LI, 6 congenital ichthyosiform erythroderma/CIE, 5 epidermolytic ichthyosis/EI) and 14 healthy controls were collected and analyzed by gene microarray