Gene expression differences of alcohol use disorder in human brain

Excessive alcohol consumption is a leading cause of preventable death worldwide. Neurobiological mechanisms associated with alcohol use disorder (AUD) remain insufficiently understood. Here, we provide RNA-sequencing data generated in nucleus accumbent and dorsolateral prefrontal cortex, from 114 deceased individuals: 58 AUD cases, 56 non-AUD controls. DNA methylation data on many of these same individuals is available (see GEO accession number GSE252501). Bulk RNAseq data were measured in postmortem nucleus accumbens (NAc) and dorsolateral prefrontal cortex (DLPFC) brain tissue. Illumina TruSeq Total RNA Stranded RiboZero Gold was used for library prep.