Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand
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Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand Descriptor: 1,2-ETHANEDIOL, 1-ethyl-N-(4-fluorophenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide, Bromodomain-containing protein 4, ... Authors: Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. Deposit date: 2015-07-21 Release date: 2016-01-13 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
创建时间：
2015-07-21
