Single cell transcriptome sequencing of diabetic mouse heart

Cardiovascular disease is the leading cause of mortality in individuals with diabetes. However, the specific mechanisms and cell heterogeneity underlying cardiac injury in diabetes are still unclear, making it difficult to effectively manage diabetic cardiovascular damage. Our study used leptin receptor knockout (db/db) mice as diabetic models and sequenced their hearts at different pathological stages. Our findings provide important insights for preventing and treating diabetic heart damage. Our study used leptin receptor knockout (db/db) mice as diabetic models and sequenced their hearts at different pathological stages.心血管疾病是糖尿病患者的首要致死原因。然而，糖尿病心脏损伤背后的具体机制与细胞异质性（cell heterogeneity）仍未明确，这使得糖尿病心血管损伤的有效防控面临极大挑战。本研究以瘦素受体敲除（leptin receptor knockout，db/db）小鼠作为糖尿病模型，对其不同病理阶段的心脏组织进行了测序。本研究结果为糖尿病性心脏损伤的防治提供了重要的研究思路与理论依据。本研究以瘦素受体敲除（leptin receptor knockout，db/db）小鼠作为糖尿病模型，对其不同病理阶段的心脏组织进行了测序。