ZIKV-infected A549 cells SBC Human (4*180K) lncRNA Microarray(V6.0)

Viral infection has a great impact on cellular expression profile of non-coding RNAs and genes. By microarray screening, our study identified 79 long non-coding RNAs (lncRNAs) and 140 mRNAs that were differentially expressed in human lung epithelial A549 cells infected with Zika virus (ZIKV). The bioinformatics analysis indicated that many differentially expressed lncRNAs were located in same chromosome as the differentially expressed mRNAs; and these lncRNAs and mRNAs were involved in the host responses to viral infection, including the innate immune response. The expression profiles of cellular lncRNAs and mRNAs in the mock-infected and ZIKV-infected A549 cells at 24 hp.i. were measured by microarray assay. Total RNA samples isolated from three independent experiments were used for Arraystar Human LncRNA Microarray V6.0.