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Protein arginine methyltransferase 5 (PRMT5) over-expression in hematological and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell c
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pH-Degradable, Bisphosphonate-Loaded Nanogels Repolarize Immunosuppressive Macrophages Towards Antifibrotic Liver Therapy
Liver fibrosis is a hard-to-treat disease with liver transplantation as only effective curation to this date. During disease progression, immune suppressive macrophages dominate and support fibrosis f
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RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and Is a Potential Therapeutic Target
TP53 mutations are highly associated with hepatocellular carcinoma (HCC), a common and deadly cancer. However, few primary drivers in the progression of HCC with mutant TP53 have been identified. To u
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The use of lipid sponge-like nanoparticles as carriers for macromolecules and...
Conventional ways to administer and deliver drugs have reached its limitations. These methods can be still used for small and simple molecules. However, new carriers have to be...
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Figure_3.jpg
In vitro release profile of eugenol encapsulated in nano-structured lipid carriers and free eugenol solution: Legend: *P<0.05 after two-way ANOVA test. NFE (Nanostructured formulation containing e
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