Multiregion whole exome sequencing of skin adnexal carcinomas

Skin adnexal tumors are neoplasms of the skin that show differentiation toward various skin appendages. Although some adnexal carcinomas are clinically aggressive and exhibit poor clinical outcome, their morphological diversity and rarity make them difficult to diagnose and classify for precise management. Therefore, a better understanding of the molecular features of adnexal tumors is required. This study focused on three malignant sweat gland tumors (porocarcinoma, hidradenocarcinoma and spiradenocarcinoma), and performed multiregion whole-exome sequencing (M-WES) to examine intratumoral genomic heterogeneity.