IRF8

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]

干扰素共识序列结合蛋白（Interferon consensus sequence-binding protein，简称ICSBP）属于干扰素（Interferon，简称IFN）调控因子（Interferon regulatory factor，简称IRF）家族的转录因子。该家族的蛋白质由N端区域保守的DNA结合域和C端区域的差异性调控域组成。IRF家族蛋白质与干扰素刺激响应元件（Interferon-stimulated response element，简称ISRE）结合，调节由I型干扰素（IFN-alpha和IFN-beta）刺激的基因表达。此外，IRF家族蛋白质还控制由病毒感染诱导的IFN-alpha和IFN-beta调控基因的表达。[提供者：RefSeq，2008年7月]