DEDuCT

Humans are being exposed to myriad chemicals in their daily environment including those contained in consumer goods, food, pharmaceuticals, and household products. Most of these daily use products were introduced or developed for human benefit, however, exposure to a minority of chemicals in these products can cause deleterious effects through serious damage to several organ systems. One such group of chemicals, namely, Endocrine Disrupting Chemicals (EDCs), have the ability to perturb the normal functioning of the biological system. In order to screen such chemicals in our daily life, we have developed a detailed workflow which was employed to process more than 16000 scientific abstracts to identify EDCs with supporting evidence for endocrine disruption upon exposure based on the observed endocrine-mediated endpoints specific to humans or rodents. Using our workflow, we identified 686 potential EDCs with supporting evidence of systems-level endocrine-mediated endpoints in published literature spanning 1796 research articles specific to humans or rodents

人类在日常生活环境中会接触到种类繁多的化学物质，这类物质存在于消费品、食品、药品及家用产品之中。此类日常用品大多为造福人类而被研发推广，但其中少数化学物质的暴露可通过损伤多个器官系统，引发有害健康效应。其中一类典型化学物质即为内分泌干扰物（Endocrine Disrupting Chemicals, EDCs），它们能够干扰生物系统的正常生理功能。为筛查日常生活中存在的这类化学物质，我们开发了一套详细的分析流程，用于处理超过16000篇科学摘要，基于针对人类或啮齿类动物的内分泌介导观测终点，筛选出具备暴露后内分泌干扰佐证证据的化学物质。依托该分析流程，我们在涵盖1796篇针对人类或啮齿类动物的已发表研究论文的文献中，鉴定出686种具备系统级内分泌介导终点佐证证据的潜在内分泌干扰物。

搜集汇总

背景与挑战

背景概述

DEDuCT是一个数据库，旨在通过人工整理人类或啮齿动物相关文献，编译具有内分泌干扰支持证据的潜在内分泌干扰物（EDCs）。当前版本3.0包含1043个潜在EDCs，源自3269篇研究文章，并提供化学信息、分类及系统级扰动等数据。