Effect of HOXC6 deletion on gene expression in Ewing Sarcoma cell line RD-ES.

The early diagnosis of Ewing sarcoma (ES) is crucial for improving patient prognosis. This study has identified new diagnostic biomarkers for ES and evaluated the in vitro effect of HOXC6 on the RD-ES cell line. Experimental results demonstrated that HOXC6 knockout inhibited ES cell proliferation and migration. To investigate the specific mechanisms by which HOXC6 knockout promotes RD-ES cell proliferation and migration, we conducted sequencing analysis on the HOXC6-knockout cells. To examine the precise influence of HOXC6 knockdown on proliferation and migration in the Ewing sarcoma RD-ES cell line, we established an shHOXC6 RD-ES cell line.