Stop codon mutations fulfilling the criteria previously described.^*

*MAF < 5%, mutation giving rise to stop codon, >9 carriers in our sample, nominally significant association with hs-GH (P<0.05), mutation disrupting > 80% of the protein and present in all splice variants. †Original amino acid, amino acid no ‡Number of amino acids in the predicted amino acid sequence §Number of homozygous carriers for minor allele, heterozygous and homozygous carriers for major allele respectively ¶Number of carriers in which values of hs-GH were available #Minor allele frequency in our sample **The β coefficients are expressed as the increment of standardized values of the natural logarithm of hs-GH per 1 minor allele. NB hs-GH is standardized separately in men and women before being used in the combined analysis. “Relation to hs-GH” shows the association from linear regression models adjusted for sex and age. Stop codon mutations fulfilling the criteria previously described.*