Associations between mitochondrial variants and advanced AMD.

Odds ratios (ORs) are ratios of the odds of having the less commonly observed allele among people with advanced (Adv.) age-related macular degeneration (AMD) to the odds of having this variant within their AMD-free peers. Values higher than 1.0 suggest an increased likelihood of having advanced AMD associated with presence of the less commonly observed allele. Advanced AMD was classified as neovascular AMD or geographic atrophy of the macula (n = 215); No AMD (n = 99), these people were essentially free of age-related macular abnormalities with a drusen area of less than 5 small drusen (Table 2).