Supplementary materials: Effects of cardiovascular single pill combinations compared with identical multi-pill therapies on healthcare cost and utilization in Germany

These are peer-reviewed supplementary materials for the article 'Effects of cardiovascular single pill combinations compared with identical multi-pill therapies on healthcare cost and utilization in Germany' published in the Journal of Comparative Effectiveness Research.Supplementary figure 1Supplementary figure 2Supplementary figure 3Supplementary table 1Supplementary table 2Aim: This study assessed whether a single pill combination (SPC) is associated with lower direct healthcare costs. Materials & methods: Anonymized claims data of patients ≥18 years treated with drugs for cardiovascular (CV)-related diseases either as a single pill combination or multi-pill combination (follow up to 1 year) were evaluated. After propensity score matching, 59,336 out of 1,369,840 patients were analyzed. Results: In all cohorts, patients receiving a single pill combination had a lower frequency of general practitioner and specialist visits. The patients also had a significantly lower ratio of all-cause hospitalization days and number of CV-related prescriptions as well as all-cause prescriptions (with one exception) compared with those receiving a multi-pill combination. Conclusion: Direct CV-related costs were significantly lower in four out of seven comparisons, with a trend toward lower costs in the other three comparisons.

本数据集为发表在《比较疗效研究杂志》上的文章《心血管单药联合疗法与相同的多药疗法在德国对医疗保健成本和利用的影响》的同行评审补充材料。包括补充图1、补充图2、补充图3、补充表1、补充表2。研究目的：本研究旨在评估单药联合疗法（SPC）是否与较低的直接医疗保健成本相关。材料与方法：评估了≥18岁接受心血管（CV）相关疾病药物治疗的患者的匿名索赔数据，包括作为单药联合疗法或多药联合疗法（随访至1年）的患者。经过倾向得分匹配后，从136,9840名患者中分析了59,336名患者。结果：在所有队列中，接受单药联合疗法的患者与一般实践者和专科医生的就诊频率较低。与接受多药联合疗法的患者相比，患者全因住院天数和CV相关处方数量以及全因处方数量（除一例外）均显著降低。结论：在七个比较中的四个比较中，直接CV相关成本显著降低，其他三个比较中存在成本降低的趋势。