Non-Canonical PRC1.1 is required for the activity of Menin-MLL1 Inhibitors in NUP98-Rearranged AML

NIAID Data Ecosystem2026-05-02 收录

急性髓系白血病

表观遗传抑制剂

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE249218 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2025-07-30

Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia [barcode-seq SG12]

急性髓系白血病

耐药性机制

Targeting the MYST acetyltransferases are an exciting therapeutic opportunity in acute myeloid leukaemia (AML). Here we define the individual and combined contribution of KAT6A, KAT6B and KAT7, in ran

NIAID Data Ecosystem90

Supplementary Table 2 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

急性髓系白血病

转录因子调控

Transcription Factor Enrichment Analysis of MOLM13 Bulk RNA-Seq (24 Hours After Drug Treatment)

Figshare2023-07-05 更新40

3H‑Pyrazolo[4,3‑f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo

急性髓系白血病

激酶抑制剂发现

The 3H-pyrazolo[4,3-f]quinoline moiety has been recently shown to be a privileged kinase inhibitor core with potent activities against acute myeloid leukemia (AML) cell lines in vitro. Herein, vario

Figshare2021-07-21 更新10

Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia [RNA-Seq]

急性髓系白血病

基因表达分析

A hallmark of acute myeloid leukemia (AML) is the inability of self-renewing malignant cells to mature into a non-dividing terminally differentiated state. To better understand how chromatin factors s

干细胞与再生医学数据中心2022-02-20 更新60

Additional file 1 of A deconvolution method and its application in analyzing the cellular fractions in acute myeloid leukemia samples

细胞组分反卷积

急性髓系白血病

Additional file 1: Table S0. Datasets and their application in this study. Table S1. Gene Ontology (Biological Processes (BP)) annotation for the marker genes identified by LinDeconSeq. Table S2. Gold

Figshare2024-02-23 更新30

Non-Canonical PRC1.1 is required for the activity of Menin-MLL1 Inhibitors in NUP98-Rearranged AML

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