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RNA-seq for analysis of the hippocampus from aged and young adults mice
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2022-10-25
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Sex- and age-dependent genetics of longevity in a heterogeneous mouse population. Sex- and age-dependent genetics of longevity in a heterogeneous mouse population
DNA variants that modulate lifespan provide insight into determinants of health, disease, and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program (ITP), we detected a sex-
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Dietary thiols accelerate aging of C. elegans
We report here on the effects of prolonged supplementation and chronic restriction ofthe major cellular thiol antioxidants, NAC and GSH, on C. elegans physiology and lifespan. Nematodes proved to be a
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Foxo signaling declines with age. Foxo signaling declines with age
We performed RNA-seq for WT and foxo mutant flies, by combining with Dr. Baihua's foxo chip-seq data, we found 101 foxo-repressed and 300 foxo-activated genes. By analyzing expression change of these
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Age-related alterations in Wnt-signaling in paneth and stem cells isolated from intestinal crypts.
Purpose: Characterize functional alterations in stem cells and paneth cells obtained from young and aged mice, focusing on age-based impairment of intestinal regeneration due to a decline in canonical
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Transcriptional and epigenetic landscape of the mouse intestine during aging identifies key molecular drivers of aging -associated dysfunctions and diseases. [Total RNA-seq - Lgr5]. Transcriptional and epigenetic landscape of the mouse intestine during aging identifies key molecular drivers of aging -associated dysfunctions and diseases. [Total RNA-seq - Lgr5]
Aging is a complex multifactorial process leading to the loss of tissue/organ functionality and to an increase in disease risk. Aging-related intestinal dysfunctions include loss of barrier integrity,
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