Purpose: The aim of this experiment was to determine the effect of SNAT1 loss on Th1 and Th17 cells. Methods: SNAT1 was knocked out using CRISPR/Cas9 in primary CD4+ T cells polarized to Th1 and Th17

NIAID Data Ecosystem50

Auxin-independent NAC pathway regulates cell wall metabolism in response to explant-specific wounding during regeneration in Arabidopsis II. Arabidopsis thaliana

再生分子机制

细胞代谢调控

In this study, through a genome-wide transcriptome analysis of wounding in the leaf explant, we identified NAC1 (petunia NAM and Arabidopsis ATAF1, ATAF2, and CUC2) family transcription factor gene th

NIAID Data Ecosystem30

Metabolic Reprogramming and Tunneling Nanotubes Cooperate to Regulate HIV-1 Latency Reactivation

HIV潜伏机制

细胞代谢调控

HIV-1 latency in myeloid cells remains a major obstacle to viral eradication. Here, we applied a systems biology approach combining transcriptomics, proteomics, metabolic modeling, targeted metabolite

Figshare2026-01-14 更新70

Genomic profiles of mouse liver tissue harboring deletion of RB and/or p53, untreated or post-hepatocarcinogen treatment [expression data]

肝癌分子机制

肿瘤抑制基因

The retinoblastoma (RB) and p53 tumor suppressors are critical regulators of the cell cycle with profound impact on both normal cell biology and disease etiology. In the context of human cancers, comp

NIAID Data Ecosystem30

Protein Kinase 𝜆/𝜄 suppresses liver cancer by repressing autophagy and oxidative phosphorylation in hepatocytes.

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