Novel NIR-II 3,5-Julolidinyl aza-BODIPY for Photothermal Therapy of Gliomas Stem Cells by Brain Stereotactic Injection

Functional dyes with absorption in the second near-infrared
window
(NIR-II) show great promise in photothermal therapy. Herein, the novel
NIR-II 3,5-julolidinyl aza-BODIPY (JLD) was prepared
and confirmed by X-ray crystallographic analysis for the first time.
The molecular packing structure facilitates the J-aggregation packing mode. Self-assembled JLD-nanoparticles
(JLD-NPs) emit fluorescence (λem = 962
nm, Φf = 0.1%), and a peak belt covered a NIR-II
range of 900–1300 nm. The photothermal conversion efficiency
was high and was calculated to be 79%. JLD-NPs with NIR-II
915 nm laser irradiation had the good tumor-inhibition capability
with promoting the apoptosis and inhibiting the stemness of glioblastoma
cells by brain stereotactic injection and affect the occurrence of
malignant events, such as migration and invasion.