Identification of genes regulated by Foxc1, which is a host target of miR-138. Identification of genes regulated by Foxc1, which is a host target of miR-138

In other parts of this study we identified Foxc1 as a host target of miR-138 and found that Foxc1 can promote herpes simplex virus-1 (HSV-1) replication. To understand the mechanisms of this function, we performed an RNAseq experiment comparing vector (pcDNA) and pFoxchuman transfected Neuro-2a cells. After transfection, these cells were infected with HSV-1 for 5 hours at an MOI of 1 to identify viral genes regulated by Foxc1 as well as host genes. Overall design: We transfected Neuro-2a cells with pFoxc1human for 40 hours and then infected with KOS for 5 hours at an MOI of 1 before RNAseq analysis of these cells. This dataset contain three replicates for pcDNA transfected cells and three replicates for pFoxc1human transfected cells.