Characterization of Lytic Phages of Klebsiella pneumoniae and Its Application of Phage Therapy. viral metagenome

Successful application of phage therapy in the treatment of K. pneumoniae infection requires a detailed understanding of phage-host interactions in both planktonic and biofilm forms, especially with regards to the phenotypic and genotypic complexity of both phage and bacterial hosts. For instance, virulent phage managing to coexist with their bacterial host leads to continuous variations and selections towards the adaptation of bacterial hosts by evolving resistance, imposing a strong selection for bacterial mutations with reduced susceptibilities or resistance against phage infection to help to preserve bacterial lineages, dictating the evolutionary dynamic of bacterial host in pathogenesis. In an attempt to establish efficient phage control of a diverse nosocomial infection, a large and well-characterized collection of phages is required which, in combination, covers a broad range of hosts.