MOESM10 of Global impact of somatic structural variation on the DNA methylome of human cancers

Additional file 10. Related to Fig. 5. SSVs associated with rearrangement of regions with high or low methylation. Using a dataset of DNA methylation of normal tissues, the average DNA methylation represented by the rearranged region (using window of 50 kb) was compared with that of the CGI nearby the gene on the other side of the SSV breakpoint, with the average difference in methylation beta values computed for all SSV-CGI associations, as well as for the subset of SSV-CGI associations involving higher or lower DNA methylation (defined using distance metric FDR < 5% and methylation in cancer sample either > 0.4SD or < − 0.4SD from sample median for the case harboring the breakpoint).