CCL17 promotes colitis - associated tumorigenesis dependent on the microbiota
收藏NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP396008
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Despite a similar degree of inflammation in the colon, CCL17-deficient mice developed fewer tumors than CCL17-competent mice. This protective effect was abrogated by cohousing, indicating a dependency on the microbiota. Changes in microbiota diversity and composition were detected in separately housed CCL17-deficient mice and these mice were more susceptible to AOM-induced early apoptosis in the colon affecting tumor initiation.
创建时间：
2022-09-10
