Plasma histidine as biomarker for recurrent atrial fibrillation after catheter ablation

Atrial fibrillation (AF) is associated with complex and multifaceted etiology including neural modulation that alters atrial electrophysiology. To explore potential biomarkers for AF and AF recurrence. Peripheral histidine levels in PeAF were significantly higher compared to those in the right atrium and coronary sinus. Receiver operating characteristic (ROC) analysis revealed that peripheral histidine was predictive of AF recurrence, with an optimal cutoff value of ≤ 4.71 µg/mL, yielding a sensitivity of 76.3% and a specificity of 76.5%. The area under the ROC curve (AUC) was 0.75 (95% CI, 0.59–0.90). Peripheral His was robustly associated with lower incidence of AF recurrence after covariates adjustment (OR 0.34, 95% CI 0.14- 0.71, p=0.01).心房颤动（Atrial fibrillation）的病因复杂且多维度，涵盖可改变心房电生理特性的神经调节等多种致病机制。为探索心房颤动及其复发的潜在生物标志物，本研究开展相关分析后发现：PeAF患者的外周血组氨酸水平显著高于右心房与冠状窦样本。受试者工作特征（Receiver operating characteristic, ROC）分析显示，外周血组氨酸可预测心房颤动复发，其最佳截断值为≤4.71 µg/mL，对应的灵敏度为76.3%、特异度为76.5%；ROC曲线下面积（Area Under the ROC Curve, AUC）为0.75（95%置信区间：0.59~0.90）。在校正混杂因素后，外周血组氨酸水平与更低的心房颤动复发风险显著相关（比值比（Odds Ratio, OR）=0.34，95%置信区间：0.14~0.71，p=0.01）。