High-throughput design and refinement of stable proteins using sequence-only models

NIAID Data Ecosystem2026-05-01 收录

蛋白质设计

稳定性优化

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High-throughput design and refinement of stable proteins using sequence-only models

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2024-04-03

Structural basis of Bacillus anthracis MoxXT disruption and the modulation of MoxT ribonuclease activity by rationally designed peptides

抗菌策略

蛋白质设计

Bacillus anthracis MoxXT is a Type II proteic Toxin–Antitoxin (TA) module wherein MoxT is a ribonuclease that cleaves RNA specifically while MoxX interacts with MoxT and inhibits its activity.

DataCite Commons2020-09-05 更新270

Integrating linear optimization with structural modeling to increase HIV neutralization breadth

蛋白质设计

HIV广谱中和抗体

Computational protein design has been successful in modeling fixed backbone proteins in a single conformation. However, when modeling large ensembles of flexible proteins, current methods in protein d

NIAID Data Ecosystem40

Crystal structure of a de novo designed parallel four-helix coiled coil, 3-EK-4

蛋白质设计

结构生物学

Crystal structure of a de novo designed parallel four-helix coiled coil, 3-EK-4

NIAID Data Ecosystem10

Solution NMR Structure of de novo design protein 312 parent

蛋白质结构解析

蛋白质设计

Solution NMR Structure of de novo design protein 312 parent Descriptor: De novo design protein 312 parent Authors: McShan, A.C, Simma, M.K. Deposit date: 2024-01-11 Release date: 2024-08-07 Last modif

Protein Data Bank Japan2025-08-20 更新70

Solution structure of the model miniprotein EEHEE_rd4_0642

蛋白质结构解析

蛋白质设计

Solution structure of the model miniprotein EEHEE_rd4_0642 Descriptor: Miniprotein EEHEE_rd4_0642 Authors: Houliston, S, Carter, L, Baker, D, Arrowsmith, C.H, Rocklin, G. Deposit date: 2023-04-19 Rele

Protein Data Bank Japan2026-05-13 更新30

High-throughput design and refinement of stable proteins using sequence-only models

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