Crystal structure of PDE5 in complex with inhibitor LW1634

Crystal structure of PDE5 in complex with inhibitor LW1634 Descriptor: 3-[(2H-1,3-benzodioxol-5-yl)methyl]-8-fluoro-1-(1,3-thiazol-2-yl)[1]benzopyrano[2,3-c]pyrrol-9(2H)-one, MAGNESIUM ION, SULFATE ION, ... Authors: Wu, D, Huang, Y.D, Huang, Y.Y, Luo, H.B. Deposit date: 2018-05-29 Release date: 2018-09-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension. J. Med. Chem., 61, 2018