Expression data from kidney cortex of control and transgenic sgk1 mice under DOCA/NaCl treatment. Expression data from kidney cortex of control and transgenic sgk1 mice under DOCA/NaCl treatment

Serum and glucocorticoid-induced kinase 1 (SGK1) regulates blood pressure and has been implicated in inflammation and fibrosis. We have tested whether increased SGK1 activity potentiates mineralocorticoid/NaCl-induced hypertension and kidney injury. To that end we have used a transgenic mouse model with increased SGK1 activity (Tg.sgk1). This data set consists on transcriptomic analysis of kidney cortex samples to obtain differential gene expression due to excess SGK1 activity between wild type or Tg.sgk1 animals that were uninephrectomized and then treated with DOCA/NaCl Overall design: 8 total RNA samples. Four replicates from wild type (C57BL/6) mice and four replicates from Tg.sgk1 mice.