BAP1 loss triggers DNA methylomic repatterning in highly aggressive Class 2 uveal melanomas [MethylationEPIC]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE130295
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资源简介：
The strong association between BAP1 mutations and highly aggressive Class 2 uveal melanoma (UM) suggests that epigenetic alterations may play a significant role in tumor progression. Thus, we characterized the impact of BAP1 loss on methylomic repatterning in UM. Global DNA methylation was analyzed in 8 Class 1 and 4 Class 2 primary UMs and in 2 different UM cells (92.1, Mel202) engineered to inducibly deplete BAP1 with dox treatment. For the engineered cell lines, both uninduced and induced cell were analyzed with matched RNA-Seq data.
创建时间：
2020-04-10
