EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis. EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

EHD1-dependent RTK traffic regulation is a pro-oncogenic mechanism that impinges on IGF-1R in Ewing Sarcoma. Overall design: mRNA profiles of human Ewing Sarcoma cell line TC71 with doxycycline inducible EHD1 knockdown and non-targeting control.