Data from: Expansion of Proteome-wide Coxiella burnetii Comparative T-cell Epitope Prediction to Include Small Ruminant Hosts

T-cell epitopes represent sampled environmental- and self-peptides loaded into major histocompatibility complex (MHC) proteins. Bioinformatic tools have been produced to predict these interactions for many species, providing peptides of interest in vaccine development studies.Prior work by the researchers (DOI: 10.1186/s12859-021-04181-w) assessed the ability of Coxiella burnetii proteins to interact with MHC alleles in human, mouse, and cattle species, the data from which is available on the Open Science Framework repository with accession number RN6QA (DOI: 10.17605/OSF.IO/RN6QA).Presently, bioinformatic programs NetBoLAIIpan 1.0 and NetMHCpan 4.1 were employed to predict T-cell epitopes within the C. burnetii proteome for the small ruminant species and to expand cattle predictions. The new datasets available herein provide the species, amino acid sequence, position within the protein, GenBank ID, allele name, and the predicted binding strength for each tested peptide.

T细胞表位代表了从环境及自身肽段中选取，并加载至主要组织相容性复合物（MHC）蛋白中的样本。针对多种物种，已开发出生物信息学工具以预测这些相互作用，为疫苗开发研究提供了感兴趣的肽段。研究人员（DOI: 10.1186/s12859-021-04181-w）先前的工作评估了科西氏伯氏立克次氏体（Coxiella burnetii）蛋白与人类、小鼠和牛物种中MHC等位基因相互作用的能效，相关数据已存放在开放科学框架（Open Science Framework）仓库中，访问号为RN6QA（DOI: 10.17605/OSF.IO/RN6QA）。目前，生物信息学程序NetBoLAIIpan 1.0和NetMHCpan 4.1被用于预测小反刍动物物种中C. burnetii蛋白质组内的T细胞表位，并扩展牛物种的预测。本处提供的新数据集包含了物种、氨基酸序列、蛋白质内的位置、GenBank ID、等位基因名称以及每个测试肽段的预测结合强度。