Molecular interactions of mitochondria and non-mitochondria genes.

The total 4,739 genes studied are separated into nine gene groups with the number of disease genes (DG) and candidate genes (CG) in each group in parenthesis (see Table S5 for individual gene data). DG products with intracellular localization to only mitochondria (115 genes) and mitochondria-and-other-localizations (47 genes) are subsets of the 162 mitochondrial DG. The human orthologs to mouse and yeast essential genes are subsets of all 4,739 genes. The five data columns show the average number of interactions (i) of each group to all genes in the human genome (all-genes); all known human disease genes (disease-genes); all human orthologs of essential mouse genes (mouse-essential); all human orthologs of essential yeast genes; and to all nuclear-encoded human mitochondrial genes (mito-genes). The numbers in parenthesis show the median number of interactions for each group and attribute, respectively. The findings indicated distinct properties in gene molecular interactions for DG and CG, as well as for mitochondria and non-mitochondria genes.