Fetal-derived activated CD83+ ?d T cells expand in preterm infants with sepsis.

Here, we investigated ?d T cells in a longitudinal cohort of preterm neonates during the first year of life. Our data reveal dynamic postnatal maturation patterns of ?d T cell subsets, which are largely age-dependent. We report on the expansion of fetal-derived ?d T cells in preterm neonates with sepsis. Single cell transcriptome analyses identified HLA-DRhigh and CD83+ ?d T cells in neonatal sepsis. Overall design: Combined single-cell transcriptome (scRNA-seq) and single-cell ?dTCR-seq (scTCR-seq) analysis was conducted from peripheral blood.