OxyTarget mtDNA seq

We studied 44 rectal cancer patients enrolled onto a prospective population-based biomarker study, who were planned for curative-intent radiation therapy before definitive surgery, yet at high risk of metastatic progression beyond the pelvic cavity. The patients had full-length mtDNA sequencing of whole blood (WB) and peripheral blood mononuclear cells (PBMC), sampled at the time of diagnosis. Metastatic events were recorded up to 60 months of follow-up after completion of the multimodal treatment.

本研究纳入了44例直肠癌细胞患者，这些患者参与了一项前瞻性基于人群的生物标志物研究，并计划在最终手术前接受根治性放疗，但存在盆腔腔外转移高风险。患者在诊断时进行了全血（WB）和外周血单个核细胞（PBMC）的全长线粒体DNA（mtDNA）测序。在多模式治疗后，记录了直至治疗后60个月的随访期间的转移事件。