Enantioselective Synthesis of Pyrrole-Fused Piperazine and Piperazinone Derivatives via Ir-Catalyzed Asymmetric Allylic Amination

Ir-catalyzed intramolecular asymmetric allylic amination reaction of pyrrole derivatives was achieved. The pyrrole-fused piperazine and piperazinone derivatives could be easily accessed from the pyrrole-tethered allylic carbonates in good yields and enantioselectivity (up to 98% ee).