Campomanesia adamantium Peel Extract in Antidiarrheal Activity: The Ability of Inhibition of Heat-Stable Enterotoxin by Polyphenols

<b>Figure 1. Effect of <i>Campomanesia adamantium</i> peel extract on cGMP levels in T84 cells.</b> Cells were pretreated with extract (0.25, 0.5, 1, 2.5, 5 and 10 mg/mL) or vehicle (DPBS) for 10 min and then treated with 1 µM of STa for 10 min. STa was added in groups of <i>C. adamantium</i> (all concentrations), Tadalafil e FPIPP. TAD (tadalafil) and FPIPP (antidiarrheal drug) was used as control drugs that increase and decrease cGMP levels, respectively. Results are presented as mean + SEM. n=4-6; One-way ANOVA followed by Tukey´s test; #P &lt;0.05 compared to baseline group; *P &lt;0.05 compared to STa group.