During the follow-up period, a new diagnosis of lung cancer was made in 145 patients (5·5%).*Multivariate logistic regression model adjusted for age and current treatment.Risk factors for a new diagno
In this work we demonstrate that the most common recurrent deletions in clonal hematopoiesis are the result of PARP1 dependent repair of DSBs by a sub-pathway of the MMEJ that is POLQ independent.
Clonal hematopoiesis (CH) is a common premalignant state in the blood and confers an increased risk of blood cancers and all-cause mortality. Identification of therapeutic targets in CH has been hinde
Therapy-related myeloid neoplasms (tMN) represent a fatal consequence of exposure to cytotoxic therapy administered in the treatment of cancer. Individuals with pre-existing TP53 clonal hematopoiesis
