Regulation of the oxido-reductive D-galactose catabolic pathway and the pentose catabolic pathway (PCP) in A. nidulans.

Genes of the PCP are regulated by the transcriptional activators XlnR (blue lines) and AraR (pink lines). Some of the D-galactose oxido-reductive genes are under regulatory control of GalR (green lines) together with XlnR and AraR. The expression of the hexokinase gene (hxkA) is observed in the A. nidulans ΔΔΔ triple mutant strain, probably due to the fact that this enzyme is also a part of glycolysis and therefore constitutively expressed. Some of the enzymatic conversions of the D-galactose oxido-reductive and the PCP pathway are verified, whereas others still need to be verified (marked by a star). Regulation of genes represented by solid lines is confirmed by expression analysis; dotted lines indicate that this regulation still needs to be verified. Dashed lines represent direct or indirect induction of TFs by monomer. Ortholog of ladB: AN4336, ortholog of red1: AN7914, ortholog of sdhA: AN2666.