Lewis Acid Catalyzed Annulation of Donor–Acceptor Cyclopropane and <i>N</i>‑Tosylaziridinedicarboxylate: One-Step Synthesis of Functionalized 2<i>H</i>‑Furo[2,3‑<i>c</i>]pyrroles

An efficient MgI2-catalyzed annulation between donor–acceptor cyclopropane and N-tosylaziridinedicarboxylate to access highly substituted 2H-furo­[2,3-c]­pyrrole bearing two rings and four stereocenters, including one quaternary carbon stereocenter, has been developed. This methodology can be used for the synthesis of biologically active compounds like IKM-159. This work also offers an insight into the mechanism of the annulation process.