MAPK6 binds CCND3

MAPK6 interacts with Cyclin D3 (CCND3) through its C-terminal extension, and this interaction is stabilized by overexpression of CDC14 phosphatase (Sun et al, 2006; Hansen et al, 2008). Although the physiological relevance of the interaction between MAPK6 and CCND3 is not known, both proteins regulate cell cycle entry and MAPK6 is stabilized during differentiation and upon inhibition of proliferation (Coulombe et al, 2003; Bartkova et al, 1998; Julien et al, 2003).

MAPK6通过与C端延伸区域与Cyclin D3（CCND3）相互作用，此相互作用通过CDC14磷酸酶（Sun et al，2006；Hansen et al，2008）的过表达而得到稳定。尽管MAPK6与CCND3之间相互作用的生理相关性尚不明确，但两者均调控细胞周期进入，且MAPK6在分化期间以及增殖抑制过程中得到稳定（Coulombe et al，2003；Bartkova et al，1998；Julien et al，2003）。