The allele frequencies and genotype distributions of the six SNPs of the TIMP3 gene in HAPE-s and HAPE-r subjects.

Allele frequencies and genotype distributions were expressed as decimals. SNPs = single nucleotide polymorphisms; HAPE-s = subjects susceptible to high-altitude pulmonary edema; HAPE-r = subjects resistant to high-altitude pulmonary edema. OR = odds ratio, 95% CI = 95% confidence interval.*1/2 indicated ancestral allele/derived allele according to the NCBI dbSNP database.†P value was calculated by Chi-square test (2×2 contingency table).‡P value was calculated by 2×2 contingency table assuming dominant mode (11/12+22) of inheritance on HAPE-s.§P value was calculated by 2×2 contingency table assuming recessive mode (11+12/22) of inheritance on HAPE-s.||P = 0.009, OR = 0.28, 95% CI = 0.10–0.76.#OR = 0.21, 95% CI = 0.08–0.57.