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4NQO-induced SOCC mice

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https://www.ncbi.nlm.nih.gov/sra/ERP146372
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Anti-PD-1 immune checkpoint inhibitor (ICI) has shown moderate efficacy in some patients with head and neck squamous cell carcinoma (HNSCC). It is imperative to establish a mouse tumor model to explore mechanisms of antitumor immunity and to develop novel therapeutic options. We examined the 4-nitroquinoline-1-oxide (4NQO)-induced oral squamous cell carcinoma (OSCC) model for genetic aberrations, transcriptomic profile, and immune cell compositions at different pathological stages.
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2023-04-21
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