A Central Role for PRC1 in Shaping the 3D Nuclear Landscape
收藏NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE134826
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资源简介：
1. Loss of RING1B substantially disrupts nuclear architecture. 2. PRC1 mediated looping can occur at a Mb scale and is independent of CTCF. 3. Polycomb mediated looping is driven by canonical PRC1 complexes. 4. Trimeric PRC1-mediated interactions occur in vitro and in vivo. 5. Gene up-regulation does not directly lead to the loss of PRC1 loops. Hi-C analysis of WT, RING1B I53A and RING1B KO E14 mouse ES cells; 4 replicates for WT and 2 replicates each, for both mutants.
创建时间：
2020-06-10
