Catalytic Enantioselective Reductive Alkynylation of Amides Enables Unified One-Pot Syntheses of Pyrrolidine，Piperidine and Indolizidine Alkaloids

1. General information Supplementary Fig 1. The Structures of All Amides Used Supplementary Fig 2. The Structures of All Alkynes Used 2. Synthesis of Materials. 2.1 Synthesis of amides 2.2 Synthesis of alkyne 2l 3. Supplementary Methods. 3.1 One-pot Catalytic Asymmetric Reductive Alkynylation of Tertiary Amides 3.2 One-pot Catalytic Asymmetric Synthesis of (–)-cis-2-Methyl-6-nonyl-piperidine Alkaloid [(–)-(2S,6R)-A-3]) 3.3 One-pot Catalytic Asymmetric Synthesis of (–)-cis-2-Methyl-6-undecyl-piperidine Alkaloid [(–)-(2S,6R)-A-4] 3.4 One-pot Catalytic Asymmetric Synthesis of Alkaloid (−)-cis-197F [(–)-(2S,6R)-A-5] 3.5 One-pot Catalytic Asymmetric Synthesis of Alkaloid (−)-cis-225C [(–)-(2S,5R)-A-2] 3.6 One-pot Catalytic Asymmetric Synthesis of Alkaloid (−)-cis-1,2-Dimethyl-6-nonyl-piperidine [(−)-(2S,6R)-A-6] 48 3.7 One-pot Catalytic Asymmetric Synthesis of Alkaloid (–)-Bgugaine [(–)-(R)-A-1)] 3.8 One-pot Catalytic Asymmetric Synthesis of Alkaloid (+)-Bgugaine (ent-A-1) 3.9 One-pot Catalytic Asymmetric Synthesis of Alkaloid (–)-209D [(–)-A-7] 3.10 One-pot Catalytic Asymmetric Synthesis of Alkaloid (+)-Monomorine I [(+)-A-8)] 3.11 One-pot Catalytic Asymmetric Synthesis of Intermediate 4a 4. Supplementary Notes 4.1 NMR Spectra of Compounds 5. Supplementary References