Suppression of Drug Resistance in Bacteria by Mg2+ Reduction through Extracellular Adenosine

This paper presents the effects of extracellular ATP, ADP, AMP, and adenosine on the occurrence of streptomycin resistance in E.coli. Results from this research show that extracellular ATP and adenosine decreased the occurrence of streptomycin resistant mutants, while extracellular ADP and AMP increased the occurrence of streptomycin resistant mutants. These compounds appear to influence the mutatability of E.coli for resistance to streptomycin by affecting the levels of Mg²⁺ in the cell.