PTSD

Posttraumatic stress disorder (PTSD) is a complex syndrome that occurs following exposure to a potentially life threatening traumatic event. Etiology and pathogenesis of PTSD research has largely focused on two main factors: genetic vulnerability and environment triggers. The estimated heritability of PTSD from twin studies is at 0.3–0.4. Studies aiming to explore genetic susceptibility and environmental triggers of PTSD have been increasing in recent years. A comprehensive summary for the genetic studies of PTSD as well as gene-environment interaction studies is necessary to understand the current genetic study status and explore more reliable candidates.创伤后应激障碍（Posttraumatic Stress Disorder，PTSD）是一类在暴露于潜在致命性创伤事件后发生的复杂综合征。当前针对PTSD的病因与发病机制研究，主要聚焦于两大核心要素：遗传易感性与环境触发因素。双生子研究估算PTSD的遗传力为0.3~0.4。近年来，旨在探索PTSD遗传易感性与环境触发因素的研究日益增多。为明晰当前PTSD遗传研究的整体现状，并挖掘更可靠的候选研究靶点，对PTSD遗传研究及基因-环境交互作用研究开展全面综述十分必要。

搜集汇总

背景与挑战

背景概述

该数据集名为PTSDgene，是一个专注于创伤后应激障碍（PTSD）遗传学研究的数据库。它整合了来自已发表研究的多种遗传因素，包括基因变异和基因-环境交互作用，并提供功能注释、数据分析工具及统计信息，旨在支持PTSD的病理机制探索。数据库定期更新，是首个此类综合性资源。