The effect of Crem absence on gene expression in mouse adrenal glands

CREM (cAMP responsive element modulator) together with CREB and ATF-1 belong to the CREB family of transcriptional factors, that respond to cyclic AMP signaling and bind to cAMP responsive element (CRE) sites in promoters of selected genes. CREM can produce isoforms that have either activating or repressing functions, depending on the transcription of specific exons. In adrenal glands it is involved in the regulation of expression of genes for steroid hormone synthesis. In this dataset, we include the expression data obtained from wild-type and Crem knock-out mouse adrenal glands. 2 condition experiment: 2 strains (WT, Crem-/-). 5 biological replications per condition.CREM（cAMP应答元件调节因子，cAMP responsive element modulator）与CREB（cAMP应答元件结合蛋白，cAMP response element-binding protein）、ATF-1同属于CREB家族转录因子（transcriptional factors），可响应环磷酸腺苷（cyclic AMP，cAMP）信号通路，并结合靶基因启动子区域的cAMP应答元件（cAMP responsive element, CRE）位点。 CREM可根据特定外显子的转录模式，产生具有激活或抑制功能的不同剪接异构体。 在肾上腺组织中，CREM参与调控类固醇激素合成相关基因的表达。 本数据集包含野生型及Crem基因敲除小鼠的肾上腺组织基因表达数据，该实验设置2组实验条件，对应2种小鼠品系（WT、Crem-/-），每组条件包含5次生物学重复。